Anti-inflammatory effects of propoxazepam on different models of inflammation

  • Received 02.12.2019
  • Revised 15.01.2020
  • Accepted 28.02.2020
  • 905 Views
  • Retrieved from Vol. 5, No. 2, 2019
  • Pages 105-112

Background. Propoxazepam, 7-bromo-5-(2-chlorophenyl)-3-propoxy-1H-benzo[e][1,4]diazepin-2(3H)-one, is a promising analgesic and anticonvulsant and is on preclinical trial. Objective. The aim of the research was to study the anti-inflammatory and analgesic action of Propoxazepam. Methods. The anti-inflammatory action was evaluated by carrageenan induced rat paw edema, formalin-induced paw licking response in mice and bradykinin-induced pain response in rat models. Results. It was established for the first time that the administration of Propoxazepam caused a significant anti-inflammatory activity when tested in different in vivo chemical experimental models of induced inflammation, i.e. carrageenan-, bradykinin- and formalin-induced inflammation tests. Conclusions. Propoxazepam significantly reduced acute and sub-acute inflammation and proved its efficacy and similar to anti-inflammatory action

propoxazepam, diclofenac sodium, anti-inflammatory effect, carrageenan, formalin

https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10900

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